Methods for preparing bile acids

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United States of America Patent

PATENT NO 11161872
APP PUB NO 20200369712A1
SERIAL NO

16636260

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Abstract

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The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.

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Patent Owner(s)

Patent OwnerAddress
MEDYTOX INCCHUNGCHEONGBUK-DO 28126

International Classification(s)

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  • 2018 Application Filing Year
  • C07J Class
  • 162 Applications Filed
  • 93 Patents Issued To-Date
  • 57.41 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee, Junho Suwon-si, KR 175 567
Liu, Dejun Hubei, CN 7 31
Qian, Yingzhe Hubei, CN 2 0
Song, Yoonseok Gunpo-si, KR 2 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges893001 - 1005101520253035404550556065707580859095

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