Compositions and methods for inhibiting protein kinases
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United States of America Patent
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Oct 5, 2021
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app pub date -
Mar 29, 2018
filing date -
Mar 29, 2017
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Abstract
Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
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