Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides

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United States of America Patent

PATENT NO 11117917
APP PUB NO 20190153016A1
SERIAL NO

16268262

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Abstract

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Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

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Patent Owner(s)

Patent OwnerAddress
SIRNA THERAPEUTICS INC300 THIRD STREET CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aaronson, Jeffrey West Point, US 5 11
Busuek, Marina West Point, US 10 13
Calati, Kathleen B Rahway, US 8 47
Colletti, Steven L West Point, US 63 627
Dudkin, Vadim West Point, US 23 118
Kowtoniuk, Robert A West Point, US 6 12
Momose, Aaron West Point, US 5 11
Parmar, Rubina G West Point, US 18 59
Shaw, Anthony W West Point, US 40 343
Storr, Rachel Anne West Point, US 6 12
Tellers, David West Point, US 7 25
Tian, Lu Jamison, US 85 694
Tucker, Thomas Joseph West Point, US 17 43
Wang, Weimin West Point, US 112 2103
Yuan, Yu Orlando, US 53 669

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