Thermal inactivation of rotavirus

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United States of America Patent

PATENT NO 11103572
APP PUB NO 20200121782A1
SERIAL NO

16722393

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Abstract

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Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICESCENTERS FOR DISEASE CONTROL AND PREVENTION 4770 BUFORD HIGHWAY (K79) ATLANTA GA 30341

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Glass, Roger I Atlanta, US 13 28
Jiang, Baoming Atlanta, US 17 24
Saluzzo, Jean-Francois La-Gaude, FR 6 3

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