Cyclic peptides targeting alpha-4-beta-7 integrin
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United States of America Patent
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Jul 27, 2021
Grant Date -
May 28, 2020
app pub date -
Nov 14, 2016
filing date -
Nov 11, 2015
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Abstract
There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C═O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C═O— is a peptide.
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