Method of generating tumor-specific T cells
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United States of America Patent
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Jul 27, 2021
Grant Date -
Aug 16, 2018
app pub date -
Apr 16, 2018
filing date -
Mar 11, 2013
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Abstract
A method of treating cancer in a subject includes contacting an enriched population of T-cells obtained from cancer or tumor draining lymph nodes ex-vivo with: an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and optionally a VEGF inhibitor and/or an IL-2 receptor agonist, at amounts effective to activate and expand the T-cells and administering the activated and expanded T-cells to the subject.
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