Inhibitors of DUX4 induction for regulation of muscle function

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United States of America Patent

PATENT NO 11065243
APP PUB NO 20200330452A1
SERIAL NO

16753247

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Abstract

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Disclosed are methods and compositions for the treatment of facioscapulohumeral muscular dystrophy. In some cases, the methods and compositions involve the use of kinase inhibitors include Src, Syk, Abl, Tie, Flt, ErbB, Trk, PRKDC, and Yes families to repress DUX4 expression in muscle cells. Further disclosed are methods and cell based assays for screening compounds for the treatment of facioscapulohumeral muscular dystrophy.

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Patent Owner(s)

Patent OwnerAddress
SONIC MASTER LIMITEDROAD TOWN VG1110 TORTOLA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kiselyov, Alexander San Diego, US 29 280
Rickard, Amanda San Diego, US 4 7
Schmidt, Uli San Diego, US 8 17

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