Conjugates of CC-1065 analogs and bifunctional linkers

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United States of America Patent

PATENT NO 11052155
APP PUB NO 20170274090A1
SERIAL NO

15461560

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Abstract

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This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

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Patent Owner(s)

Patent OwnerAddress
BYONDIS B VMICROWEG 22 NIJMEGEN 6545 CM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beusker, Patrick Henry Nijmegen, NL 17 525
Coumans, Rudy Gerardus Elisabeth Nijmegen, NL 18 108
De, Groot Franciscus Marinus Hendrikus Nijmegen, NL 12 493
Elgersma, Ronald Christiaan Nijmegen, NL 11 58
Joosten, Johannes Albertus Frederikus Nijmegen, NL 12 133
Menge, Wiro Michael Petrus Bernardus Nijmegen, NL 5 37
Spijker, Henri Johannes Nijmegen, NL 10 135

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