Multispecific binding constructs against checkpoint molecules and uses thereof
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United States of America Patent
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Jun 29, 2021
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Jun 11, 2020
app pub date -
Nov 13, 2019
filing date -
Nov 13, 2018
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Abstract
The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.
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