Application of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate in preparation of medicament for treating psoriasis and vitiligo

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United States of America Patent

PATENT NO 11045475
APP PUB NO 20190216817A1
SERIAL NO

16314024

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Abstract

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Provided in the present invention is a use of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate in the preparation of a medicament for treating psoriasis and vitiligo. More specifically, the present invention uses mice whose psoriasis is induced by an imiquimod cream to observe a changing condition in skin lesions on the psoriasis-like mice, according to a psoriasis skin lesion area of the mice and grading standards for disease severity; the present invention also observes a proportion of lymphocytes in the spleens and cytokines in skin lesion tissues of the mice. A good therapeutic effect may be obtained by treating typical cases of vitiligo with an ointment of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate. Results show that methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate used in the present invention has a good therapeutic effect on psoriasis and vitiligo, as well as a favorable prospect in clinical application.

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Patent Owner(s)

Patent OwnerAddress
NINGBO ZIYUAN PHARMACEUTICALS INCNO 439 XINGHAI ZHONG LU YUELONG STREET NINGHAI COUNTY NINGBO ZHEJIANG 315600
SHANGHAI INST OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES555 ZU CHONG ZHI ROAD ZHANG JIANG PUDONG SHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lin, Zemin Shanghai, CN 7 1
Tang, Wei Shanghai, CN 217 3421
Yuan, Chongsheng San diego, US 1 0
Zuo, Jianping Shanghai, CN 18 101

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