Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof

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United States of America Patent

PATENT NO 11040952
APP PUB NO 20200181109A1
SERIAL NO

16786710

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Abstract

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Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCESSHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Wuhong Shanghai, CN 7 11
Hu, Youhong Shanghai, CN 13 73
Liu, Feifei Shanghai, CN 11 12
Lu, Dong Shanghai, CN 47 1249
Tong, Xiankun Shanghai, CN 3 2
Yang, Li Shanghai, CN 438 2742
Zeng, Limin Shanghai, CN 3 8
Zhang, Yunzhe Shanghai, CN 1 0
Zuo, Jianping Shanghai, CN 18 101

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