Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof
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United States of America Patent
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Jun 8, 2021
Grant Date -
May 28, 2020
app pub date -
Jul 6, 2018
filing date -
Jul 10, 2017
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Abstract
The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.
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