Crystals of anti-human PD-1 monoclonal antibodies
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United States of America Patent
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May 25, 2021
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Aug 23, 2018
app pub date -
Feb 22, 2016
filing date -
Feb 27, 2015
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Abstract
Crystals of pembrolizumab and structurally similar anti-PD-1 monoclonal antibodies are provided, as well as methods of producing such crystals, and uses of compositions comprising such antibody crystals, e.g. in treatment of cancers. The present invention satisfies these needs and more by providing pembrolizumab crystals and a method producing pembrolizumab crystals. One embodiment of the method of the invention produces crystals suitable for X-ray diffraction, and the inventors herein used such crystals to solve the three-dimensional structure of pembrolizumab to 2.3 A resolution.
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