Methods of increasing delivery of anti-cancer agents to targets
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United States of America
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Apr 13, 2021
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Jan 4, 2018
app pub date -
Jan 15, 2016
filing date -
Jan 15, 2016
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Abstract
The present invention provides compositions and methods for increasing the permeability of a stroma around a neoplasm, and particularly to cancer cells associated with solid tumors. In one embodiment, combining a therapeutic IgE antibody with an anti-cancer agent in accordance with the invention increases the delivery of the anticancer agent to the site of, for example, a solid tumor in a subject. In one embodiment, combining a therapeutic IgE antibody with an anti-cancer agent in accordance with the invention potentiates a tumor's responsiveness and sensitivity to the anti-cancer agent.
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