Pharmaceutical composition for preventing and treating cancer, containing CYB5R3 gene or protein as active ingredient
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United States of America
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Apr 13, 2021
Grant Date -
Aug 18, 2016
app pub date -
Mar 31, 2016
filing date -
Mar 31, 2016
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Abstract
The present invention relates to a pharmaceutical composition for treating cancer, containing cytochrome b5 reductase 3 (CYB5R3) protein as an active ingredient. Over-expression of CYB5R3 in cancer cells results in significant reduction of hypoxia-inducible factor-1α (HIF-1α) expression, which leads inhibition of cancer cells growth in vitro and in vivo. Thus, the CYB5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for treating cancer.
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