Anti-CXCR4 antibodies and antibody-drug conjugates

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United States of America Patent

PATENT NO 10927178
APP PUB NO 20200102394A1
SERIAL NO

16535477

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Abstract

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The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.

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Patent Owner(s)

  • PFIZER INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ho, Wei-Hsien Belmont, US 33 621
Liu, Shu-Hui Redwood City, US 27 359
Pernasetti, Flavia Mercer San Diego, US 5 24

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