Systems and methods for quantifying the impact of biological perturbations
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United States of America Patent
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Feb 9, 2021
Grant Date -
Aug 17, 2017
app pub date -
Dec 20, 2016
filing date -
Jun 10, 2011
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Abstract
Systems and methods are described for quantifying the response of a biological system to one or more perturbations. First and second datasets corresponding to a response of a biological system to first and second treatments are received. A plurality of computational network models that represent the biological system are provided, each model including nodes representing a plurality of biological entities and edges representing relationships between the nodes in the model. A first set of scores is generated, representing the perturbation of the biological system based on the first dataset and the plurality of models, and a second set of scores representing the perturbation of the biological system based on the second dataset and the plurality of computational models. One or more biological impact factors are generated based on each of the first set and second set of scores that represent the biological impact of the perturbation on the biological system.
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