Processes and intermediates for NEP inhibitor synthesis

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United States of America Patent

PATENT NO 10851059
APP PUB NO 20190202785A1
SERIAL NO

16325880

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Abstract

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The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS PHARMA AGLICHTSTRASSE 35 BASEL 4056

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kleinbeck-Riniker, Florian Karl Zurich, CH 6 2
Mafli, Ives Zurich, CH 1 0
Martin, Benjamin Leymen, FR 35 273
Penn, Gerhard Oberwil, CH 13 17
Sedelmeier, Gottfried Schallstadt, DE 56 222
Sedelmeier, Joerg Weil am Rhein, DE 4 0
Venturoni, Francesco Saint-Louis, FR 4 3

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