Process for the preparation of acalabrutinib

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United States of America Patent

PATENT NO 10800787
SERIAL NO

16605972

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Abstract

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The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).

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Patent Owner(s)

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APOTEX INC150 SIGNET DRIVE TORONTO M9L 1T9

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bodhuri, Prabhudas San Ramon, US 19 41
Gorin, Boris Oakville, CA 39 232
Green, Melanie R A Milton, CA 5 2
Weeratunga, Gamini Ancaster, CA 45 114

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