Dibasic organic acid producing strain and preparation and application of same

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United States of America Patent

PATENT NO 10781462
APP PUB NO 20180171369A1
SERIAL NO

15551165

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Abstract

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Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved. The dibasic organic acid comprises malic acid, succinic acid, fumaric acid, oxaloacetic acid, glutaric acid, and adipic acid; the expression product of the positive regulator gene comprises aspartate aminotransferase, glutamic acid-aspartate transporter, C4-dicarboxylic acid transporter, pyruvate carboxylase and malate dehydrogenase, glucose transporter; the expression product of the negative regulatory gene comprises succinyl-CoA synthase, and malic acid-alpha ketoglutarate transporter, and the original strain comprises myceliophthora thermophila, thielavia terrestris, aspergillus, and rhizopus.

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Patent Owner(s)

Patent OwnerAddress
TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY CHINESE ACADEMY OF SCIENCESNO 32 XIQI ROAD AIRPORT ECONOMIC ZONE DONGLI DISTRICT TIANJIN TIANJIN CITY TIANJIN CITY 300308

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ji, Jingxiao Tianjin, CN 2 0
Li, Jingen Tianjin, CN 4 0
Lin, Liangcai Tianjin, CN 10 6
Liu, Qian Tianjin, CN 279 1098
Long, Chuannan Tianjin, CN 2 0
Ma, Yanhe Tianjin, CN 30 5
Sun, Tao Tianjin, CN 269 1665
Sun, Wenliang Tianjin, CN 5 7
Tian, Chaoguang Tianjin, CN 9 32
Xu, Jing Tianjin, CN 575 4672

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