System and method for preparing cryo-em grids

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United States of America Patent

PATENT NO 10770265
SERIAL NO

16823506

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Abstract

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An electron microscope (EM) preparation and imaging system including an EM device and a sample preparation device for forming a vitreous ice layer containing a liquid sample through vitrification, which are located within a sealable environment. The sample preparation apparatus includes a cryogenically-cooled stage that receives a sample deposit surface, such as a cryo-EM grid, which is cryogenically cooled through direct contact with the stage. A sample dispenser is movable with respect to the stage and is configured to deposit a liquid sample onto the sample deposit surface at a selected rate of deposition. Once the liquid sample is deposited onto the sample deposit surface by the sample dispenser, it is vitrified automatically in place.

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Patent Owner(s)

Patent OwnerAddress
APT TECHNOLOGIES LLC11429 BANCROFT LANE FARRAGUT TN 37934

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liang, Winnie Farragut, US 4 14
McQueen, Trevor Allen Farragut, US 2 6

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