Method for detecting mutations in single cells or single molecules

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United States of America Patent

PATENT NO 10752954
APP PUB NO 20160046999A1
SERIAL NO

14774543

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Abstract

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The invention provides a high efficiency fluorescence in situ hybridization (FISH) method for detecting mutations on individual RNA transcripts, including both exonic and intronic RNA transcripts. In certain embodiments, the method is used to quantify allelic expression at the population and single cell level, and also to distinguish maternal chromosomes from paternal chromosomes in single cells.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA1ST FLOOR GARDNER STEEL CONFERENCE CENTER 130 THACKERAY AVENUE PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Levesque, Marshall Rahway, US 1 1
Raj, Arjun Wynnewood, US 6 37

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