Recombinant production method

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United States of America Patent

PATENT NO 10745731
APP PUB NO 20190002947A1
SERIAL NO

16004992

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Abstract

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Herein is reported a method for the recombinant production of a polypeptide in a eukaryotic cell comprising the steps of (i) cultivating a eukaryotic cell comprising a nucleic acid encoding the polypeptide in a cultivation medium comprising a compound selected from the group consisting of trans-2-methyl 2-pentenoic acid, the broad-spectrum HDAC inhibitor Quisinostat, and the subtype-specific HDAC inhibitor Romidepsin, and (ii) recovering the polypeptide from the cell or the cultivation medium and thereby producing the polypeptide in a eukaryotic cell.

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INC340 KINGSLAND STREET NUTLEY NJ 07110

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Killian, Tobias Penzberg, DE 4 5
Neubauer, Markus Penzberg, DE 12 24

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