Methods of purifying exosomes
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United States of America Patent
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Aug 4, 2020
Grant Date -
May 23, 2019
app pub date -
Nov 21, 2018
filing date -
Nov 21, 2017
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Abstract
Exosome purification methods involve use of a whey composition as an exosome source. Exosomes are isolated by subjecting the whey composition to a first ultrafiltration, which yields a first permeate and a first retentate. The first retentate may then be subjected to a second ultrafiltration, yielding a second permeate and a second retentate. During the second ultrafiltration, the first retentate may be treated with carbon dioxide. The second retentate may then be subjected to a third ultrafiltration, yielding a third permeate and a third retentate. The third permeate may then be optionally dried to yield an exosome powder.
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