Sustained-release lipid pre-concentrate of GNRH analogues and pharmaceutical composition comprising the same
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United States of America Patent
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Jul 28, 2020
Grant Date -
Oct 22, 2015
app pub date -
Dec 27, 2013
filing date -
Dec 28, 2012
priority date (Note) -
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Abstract
Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups; b) at least one phospholipid; c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety; and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.
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