Capsular polysaccharide solubilisation and combination vaccines

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United States of America Patent

PATENT NO 10716841
APP PUB NO 20170043004A1
SERIAL NO

15339741

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Abstract

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Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilisation of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of Men A saccharide:MenC saccharide is >1.

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Patent Owner(s)

Patent OwnerAddress
GLAXOSMITHKLINE BIOLOGICALS SARUE DE L'INSTITUT 89 B-1330 RIXENSART BELGIUM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Costantino, Paolo Siena, IT 53 322

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