Method for producing radiopharmaceutical composition
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United States of America Patent
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Jul 7, 2020
Grant Date -
Sep 12, 2019
app pub date -
Feb 28, 2019
filing date -
Mar 7, 2018
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Abstract
A simple method for producing a clinically applicable radiopharmaceutical composition containing 1-(2,2-dihydroxymethyl-3-[18F]fluoropropyl)-2-nitroimidazole ([18F]DiFA) or a salt thereof as an active ingredient, is provided which includes a synthesis step of obtaining a crude product of [18F]DiFA from a labeling precursor compound for [18F]DiFA; and a purification step of purifying the crude product, in which the purification step includes purifying [18F]DiFA using two or more different types of reverse phase solid phase extraction cartridges.
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