Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure

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United States of America Patent

PATENT NO 10668094
APP PUB NO 20180207189A1
SERIAL NO

15745441

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Abstract

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Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

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Patent Owner(s)

Patent OwnerAddress
YEDA RESEARCH AND DEVELOPMENT CO LTDWEIZMANN INSTITUTE OF SCIENCE P O BOX 95 REHOVOT 7610002

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Karlish, Steven J D Rehovot, IL 3 11
Katz, Adriana Rehovot, IL 3 10
Marcovich, Arie Rehovot, IL 11 32
Tal, Daniel M Rehovot, IL 3 10

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