VC-CAR molecule and use thereof in removing HIV-1 infected cells
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United States of America Patent
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Apr 28, 2020
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N/A
app pub date -
Jan 23, 2017
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Aug 10, 2016
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Abstract
The present invention relates to a VC-CAR molecule and a use thereof in removing HIV-1 infected cells. The VC-CAR molecule is characterized by linking an HIV-1 broad-spectrum neutralizing antibody VRC01 sourced scFv sequence and an intracellular domain sequence of a conventional CAR molecule which are respectively used as extracellular and intracellular domains. A T cell modified by the VC-CAR molecule can be specifically activated and secrete a great number of cytotoxicity-related cytokines, so that lysis of a target cell can be powerfully mediated, and it can be better used for anti-infection adoptive immunotherapy.
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