Substituted 2, 4-diamino-quinoline derivatives for use in the treatment of proliferative diseases
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United States of America
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Mar 3, 2020
Grant Date -
May 16, 2019
app pub date -
May 4, 2017
filing date -
May 4, 2017
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Abstract
This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein which exhibit strong inhibition effects on various cancer cell lines. The compounds disclosed herein are useful for the treatment of proliferative diseases, including neoplastic diseases such as cancer and non-neoplastic disorders such as rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing compounds of Formula I and at least one carrier, diluent or excipient and optionally one or more additional therapeutically active agents, including anticancer agents. This application also discloses methods for treating a proliferative disease, including neoplastic diseases such as cancer and non-neoplastic disorders such as rheumatoid arthritis.
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