Rutaecarpine analogs and applications thereof
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United States of America
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Jan 7, 2020
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Oct 17, 2019
app pub date -
Apr 13, 2018
filing date -
Apr 13, 2018
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Abstract
The present invention provides RUT analogs with various biological activities. In particular, the biological activities comprise anti-inflammatory activity, vasodilator effects, migration/invasion-suppressive activities, ability against damage due to remodeling between the epithelium and endothelium, collagen deposition and cardiac fibrosis suppress, Snail protein inhibitory effect, etc., which may improve cardiac, vasodilation, and lung functions. The RUT analogs disclosed herein also exhibit a lower cytotoxicity comparing to RUT.
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