Combination therapy to enhance the anticancer efficacy of platinum drugs

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United States of America Patent

PATENT NO 10478437
APP PUB NO 20170095478A1
SERIAL NO

15380776

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Abstract

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The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION130 THACKERAY AVE 1ST FLOOR GARDNER STEEL CONFERENCE CENTER PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Qian, Wei Pittsburgh, US 127 1649
Van, Houten Bennett Pittsburgh, US 7 16
Wipf, Peter Pittsburgh, US 105 492

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