Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
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United States of America Patent
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Nov 12, 2019
Grant Date -
Sep 18, 2014
app pub date -
Apr 21, 2014
filing date -
Mar 22, 2010
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Abstract
The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
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