Methods for selecting protease resistant polypeptides
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United States of America Patent
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Nov 5, 2019
Grant Date -
Jul 3, 2014
app pub date -
Feb 10, 2014
filing date -
Dec 5, 2008
priority date (Note) -
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Abstract
The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.
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