Fermentation process for producing itaconic acid under nitrogen free conditions
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United States of America Patent
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Oct 15, 2019
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Jan 18, 2018
app pub date -
Feb 16, 2016
filing date -
Feb 16, 2015
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Abstract
The present invention relates to a method for the production of itaconic acid, which method comprises fermenting a recombinant cell capable of producing itaconic acid in a suitable fermentation medium, thereby to produce itaconic acid, wherein: (a) the recombinant cell: (i) overexpresses cis-aconitate decarboxylase; and (ii) overexpresses a part of the citric acid cycle and/or has reduced activity of a native metabolic route to acetate and/or lactate; and, optionally, (b) the fermentation is carried out under anaerobic conditions.
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