Anti-CXCR4 antibodies and antibody-drug conjugates
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United States of America Patent
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Sep 24, 2019
Grant Date -
Mar 28, 2019
app pub date -
Oct 22, 2018
filing date -
Aug 2, 2013
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Abstract
The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
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