Biodegradable cross-linked polymer and methods of preparing the same
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United States of America Patent
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Aug 27, 2019
Grant Date -
Sep 20, 2018
app pub date -
Mar 15, 2018
filing date -
Oct 9, 2012
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Abstract
A biodegradable cross-linked polymer and methods of preparing same are provided. The biodegradable cross-linked polymer is formed from a biodegradable polymeric material having two or more arms, which is a random copolymer formed of a first monomer and a second monomer different from the first monomer. The first monomer is selected from the group consisting of L-lactide, DL-lactide, glycolid, ε-caprolactone, trimethylene carbonate, p-dioxanone, amino acid-derived polycarbonates and polyorthoesters. The second monomer is one or two selected from the group consisting of D-lactide, DL-lactide, glycolide, ε-caprolactone, trimethyl carbonate, salicylic acid, carbonates, amino acids and derivatives thereof. The biodegradable polymeric material has a molecular weight of from 5,000 to 1,200,000 and an intrinsic viscosity of from 0.1 to 9.0 dl/g. Each of the terminal groups on the arms of the biodegradable polymeric material is selected from the group consisting of hydroxyl amino and carboxyl groups.
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