extract, fraction, or active fraction thereof

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United States of America Patent

PATENT NO 10376553
APP PUB NO 20180353561A1
SERIAL NO

15573207

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Abstract

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A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.

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Patent Owner(s)

Patent OwnerAddress
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYDAEJEON 34141

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahn, Kyung Seop Daejeon, KR 40 24
Kim, Doo-Young Daejeon, KR 40 133
Kim, Jung Hee Daejeon, KR 35 152
Kwon, Ok-Kyoung Daejeon, KR 20 1
Lee, Hyeong Kyu Daejeon, KR 20 11
Lee, Hyun-Jun Daejeon, KR 27 203
Lee, Su Ui Daejeon, KR 12 3
Oh, Sei-Ryang Daejeon, KR 26 10
Ryu, Hyung Won Daejeon, KR 18 1
Shin, In-Sik Gwangju, KR 5 11

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