Therapy for malignant disease
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United States of America Patent
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Aug 13, 2019
Grant Date -
May 3, 2018
app pub date -
Mar 28, 2016
filing date -
Mar 26, 2015
priority date (Note) -
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Abstract
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.
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