antigens

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United States of America Patent

PATENT NO 10369206
APP PUB NO 20130266583A1
SERIAL NO

13878150

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Abstract

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The present invention relates to recombinant Clostridium difficile antigens based on a fusion protein that consists of or comprises a first amino acid sequence and a second amino acid sequence, wherein: a) the first amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of residues 500-1850 of a C. difficile Toxin A sequence or residues 1500-1851 of a C. difficile Toxin B sequence; and b) the second amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of a long repeat unit located within amino acid residues 1851-2710 of a C. difficile Toxin A sequence or within amino acid residues 1852-2366 of a C. difficile Toxin B sequence; though with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543-2710 of a C. difficile Toxin A and with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543-2366 of a C. difficile Toxin B. Also provided is the use of said antigens for the prevention/treatment/suppression of Clostridium difficile infection (CDI), together with methods for generating said antigens, methods for generating antibodies that bind to said antigens, and the use of said antibodies for the prevention/treatment/suppression of CDI.

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Patent Owner(s)

Patent OwnerAddress
SECRETARY OF STATE FOR HEALTH AND SOCIAL CARELONDON SW1H 0EU

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahern, Helen Salisbury, GB 4 9
Landon, John Newcastle Emlyn, GB 13 60
Maynard-Smith, Michael Salisbury, GB 6 20
Roberts, April Salisbury, GB 7 51
Shone, Clifford Salisbury, GB 10 77

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