Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrom-bogenic agent
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United States of America Patent
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Jul 16, 2019
Grant Date -
Aug 28, 2014
app pub date -
Sep 25, 2012
filing date -
Sep 27, 2011
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Abstract
Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin becomes covalently attached to the amino-functionalized membrane, wherein said heparin is indirectly attached via a spacer to said amino-functionalized membrane and/or said heparin is attached from a single site in said heparin to a single site on said amino-functionalized membrane or to said spacer. Also disclosed are analyte sensors.
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