Method and system for high-throughput sequencing data analysis
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United States of America Patent
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Jun 18, 2019
Grant Date -
Jun 30, 2016
app pub date -
Dec 31, 2015
filing date -
Jun 15, 2015
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Abstract
Methods and systems for high-throughput sequencing data analysis are provided. In an embodiment, the method includes the following steps. An input DNA/RNA/Protein sequence is received by a master computing unit. The input DNA/RNA/Protein sequence is partitioned into overlapping segments with a sliding window less than a segment length of the overlapping segments to allow overlapping of any successive two thereof by the master computing unit. The overlapping segments are distributed by the master computing unit to a plurality of slave computing units in a cloud computing environment. Suffix-expansion-sorting processing is performed on the overlapping segments by the slave computing units to produce sorted expansion segments. Distributed database tables are generated based on the sorted expansion segments by at least a portion of the slave computing units. The distributed database tables are associated to construct a global database table corresponding to the input DNA/RNA/Protein sequence for high-throughput sequencing data analysis.
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