Method for detecting chromosome structure and gene expression simultaneously in single cells
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United States of America Patent
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Jun 4, 2019
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Jan 23, 2014
app pub date -
Feb 6, 2012
filing date -
Feb 4, 2011
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Abstract
The present invention relates to systems and methods for measuring chromosome structure and gene expression. In one embodiment, the present invention includes an assay for determining the spatial organization of gene expression in the nucleus. The present invention also includes a method based on fluorescence in situ hybridization (FISH) that simultaneously yields information on the physical position and expression of individual genes. By lighting up a large number of targets on a particular chromosome using a bar-coding scheme, the large scale structure of an entire chromosome can be determined.
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