Magnetic nanocompositions for highly sensitive molecular and cellular enrichment, purification and detection
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United States of America Patent
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May 28, 2019
Grant Date -
Oct 25, 2018
app pub date -
Jun 29, 2018
filing date -
Mar 31, 2012
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Abstract
The present invention relates to a method of capturing, enriching, purifying, detecting or measuring a cell in a sample at a sub-nanogram level comprising providing a nanocomposition, contacting the sample with the nanocomposition to form a mixture solution and allowing the binding of the cell with the nanocomposition, applying a magnetic field to the mixture, and evaluating the presence of or absence of the cell. The nanocomposition is capable of capturing or enriching an analyte at a sub-nanogram level, and comprise a nanostructure operably linked to an analyte-capturing member.
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