Pharmaceutical composition not containing antioxidant and preparation method therefor
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United States of America Patent
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May 28, 2019
Grant Date -
Nov 3, 2016
app pub date -
Dec 26, 2014
filing date -
Dec 30, 2013
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Abstract
Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation without use of an antioxidant. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.
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