Identification of nucleic acid template-linked barcodes comprising nucleic acid modifications
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United States of America Patent
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May 21, 2019
Grant Date -
Jun 2, 2016
app pub date -
Sep 23, 2015
filing date -
Dec 11, 2008
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Abstract
Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
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