Reduction of amyloid beta peptide production via modification of the APP gene using the CRISPR/Cas system
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United States of America Patent
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May 7, 2019
Grant Date -
Aug 24, 2017
app pub date -
May 8, 2015
filing date -
May 9, 2014
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Abstract
Methods and products are described related to use of the CRISPR/Cas9 system to introduce a modification into an APP gene, such as guide RNAs and recombinant proteins, for decreasing amyloid beta peptide produced by a cell. Also described are uses of such methods and products for the treatment of Alzheimer's disease and/or age-related cognitive decline in a cell from a subject in need thereof.
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