Transmembrane penetration enhancer
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United States of America Patent
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Apr 2, 2019
Grant Date -
Apr 26, 2012
app pub date -
Oct 25, 2010
filing date -
Oct 25, 2010
priority date (Note) -
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Abstract
A transmembrane penetration enhancer includes a thermotropic liquid crystal suitably prepared for use in a therapeutic system to improve delivery of at least one active ingredient across a biomembrane and/or skin. The thermotropic liquid crystal comprises at least one cholesteryl ester and is effective in a mesomorphic state at a temperature of the biomembrane and/or skin. A therapeutic system includes the prepared thermotropic liquid crystal for enhanced transmembrane penetration and at least one active ingredient for delivery by the thermotropic liquid crystal. A method for making and using the transmembrane penetration enhancer is presented.
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