Flavone based EGFR inhibitors and process for preparation thereof
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United States of America Patent
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Mar 5, 2019
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Jan 18, 2018
app pub date -
Feb 3, 2016
filing date -
Feb 3, 2015
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Abstract
The present invention discloses a novel EGFR inhibitor compound of formula (1), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) wherein, R is selected from hydrogen, alkyl, nitro, halogens such as chlorine, bromine, fluorine and iodine; R1=hydrogen, alkyl, alkoxy, aryl, nitro, halogens such as chlorine, bromine, fluorine and iodine, trifluoromethyl, thioalkyl, trifluromethoxy, trialkylsilyl.
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