HIF-1 modulator paint formulation and uses thereof
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United States of America Patent
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Mar 5, 2019
Grant Date -
Jul 16, 2015
app pub date -
Aug 30, 2013
filing date -
Aug 30, 2012
priority date (Note) -
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Abstract
Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
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